| 名稱 | FBXW7 p.R479Q Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10284 |
| 報價 |  |
| 特點(diǎn) | FBXW7 p.R479Q Reference Standard |
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電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10284FBXW7 p.R479Q Reference Standard 標(biāo)準(zhǔn)品
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CBP10284 | |
| Format | Genomic DNA |
| Description | FBXW7 R479Q lies within the WD 3 repeat region of the Fbxw7 protein (UniProt.org). R479Q confers a loss of FBXW7-substrate interation and impairs substrate degradation by FBXW7, resulting in sustained NICD and MYC expression (PMID: 17646409, PMID: 25450649). |
| Technical Data | |
| DNA Change | c.1436G>A |
| AA Change | p.R479Q |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 66.67% |
| Transcript | ENST00000281708 |
| Cosmic ID | COSM22974 |
| Chr position(GRCh37) | chr4:153247366 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
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| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
