| 名稱 | c-Kit W557_K558del/BaF3 |
| 型號 | CBP73233 |
| 報價 |  |
| 特點 | c-Kit W557_K558del/BaF3,母細胞：BaF3，KIT W557del 導致 Kit 蛋白近膜結(jié)構(gòu)域（外顯子 11）中氨基酸 557 處的氨基酸缺失（PMID：12918066）。 W557del 尚未表征，但類似的 Kit 外顯子 11 缺失正在激活（PMID：9438854，PMID：9797363），因此預計會導致 Kit 蛋白功能的增加。 |
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藥靶細胞株 > kinase激酶細胞株 > CBP73233c-Kit W557_K558del/BaF3
- 詳細內(nèi)容
CBP73233 | |
| I. Introduction | |
Cell Line Name： | c-Kit W557_K558del/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
KIT W557del results in the deletion of an amino acid in the juxtamembrane domain (exon 11) of the Kit protein at amino acids 557 (PMID: 12918066). W557del has not been characterized, however similar Kit exon 11 deletions are activating (PMID: 9438854, PMID: 9797363), and therefore, is predicted to lead to a gain of Kit protein function . | |
| III. Representative Data | |
1. WB of c-Kit W557_K558del/BaF3
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2.Sanger of c-Kit W557_K558del/BaF3
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3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 c-KIT W557_ K558del (C2). | |
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